diff --git a/src/corelib/Qt6CoreMacros.cmake b/src/corelib/Qt6CoreMacros.cmake
index 9e8ce544cc..9e71b4265a 100644
--- a/src/corelib/Qt6CoreMacros.cmake
+++ b/src/corelib/Qt6CoreMacros.cmake
@@ -3489,6 +3489,21 @@ macro(qt6_standard_project_setup)
         if(NOT DEFINED QT_I18N_SOURCE_LANGUAGE)
             set(QT_I18N_SOURCE_LANGUAGE ${__qt_sps_arg_I18N_SOURCE_LANGUAGE})
         endif()
+
+        if(CMAKE_GENERATOR STREQUAL "Xcode")
+            # Ensure we always use device SDK for Xcode for single-arch Qt builds
+            set(qt_osx_arch_count 0)
+            if(QT_OSX_ARCHITECTURES)
+                list(LENGTH QT_OSX_ARCHITECTURES qt_osx_arch_count)
+            endif()
+            if(NOT qt_osx_arch_count GREATER 1 AND ${CMAKE_OSX_SYSROOT} MATCHES "^[a-z]+simulator$")
+                # Xcode expects the base SDK to be the device SDK
+                set(simulator_sysroot "${CMAKE_OSX_SYSROOT}")
+                string(REGEX REPLACE "simulator" "os" CMAKE_OSX_SYSROOT "${CMAKE_OSX_SYSROOT}")
+                set(CMAKE_OSX_SYSROOT "${CMAKE_OSX_SYSROOT}" CACHE STRING "" FORCE)
+                set(CMAKE_XCODE_ATTRIBUTE_SUPPORTED_PLATFORMS "${simulator_sysroot}")
+            endif()
+        endif()
     endif()
 endmacro()